Los Angeles also has a favorable matchup against a sometimes shaky 49ers offense, but the Rams still rely on a potent offense. The Rams are very good on defense, headlined by 50 regular season sacks and various top-10 marks in the NFL. In addition, Roberts has gone an astounding 10-1 in his last 11 picks involving San Francisco. He is 10-6 against the spread in his last 16 NFL picks for a profit of $345. Roberts has worked in the Las Vegas sportsbook industry for 20-plus years, including a 13-year run as Station Casinos' book director. 49ers picks and NFC Championship Game predictions, make sure you check out what SportsLine's resident 49ers expert, Micah Roberts, has to say. Caesars Sportsbook lists the Rams as 3.5-point home favorites, while the Over-Under, or total number of points Vegas thinks will be scored, is 45.5 in the latest 49ers vs. The 49ers are 8-3 on the road, including playoffs, and San Francisco is 9-2 in its last 11 games. Los Angeles hosts the title game at SoFi Stadium, and the Rams are 6-3 at home this season. Both the Los Angeles Rams and San Francisco 49ers are 2-0 in the playoffs, with the Rams beating the Cardinals and Buccaneers and the 49ers beating the Cowboys and Packers. With the top-seeded Green Bay Packers eliminated, the NFC West steps into the spotlight in the 2022 NFC Championship Game on Sunday.
